JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 357
Type: Contributed
Date/Time: Tuesday, August 11, 2015 : 10:30 AM to 12:20 PM
Sponsor: Section on Bayesian Statistical Science
Abstract #316057
Title: Novel Hierarchical Bayesian Modeling Enables Multi-Cancer-Type 'Basket Trial' in Rare Cancers
Author(s): Elizabeth Krachey* and Kert Viele and Donald Berry and Allison Florance
Companies: Berry Consultants and Berry Consultants and MD Anderson Cancer Center and GlaxoSmithKline
Keywords: Bayesian ; Hierarchical ; Clinical Trial
Abstract:

Modern targeted therapies may be effective across a variety of organ-specific tumor types that express the target. A natural investigation of such a treatment is through a multi-tumor-type trial. Pooling data across types is inappropriate because it ignores difference by type. Separate analyses for each type fail to use potentially valuable information in other types expressing the target. We propose a hierarchical Bayesian model with novel clustering. The approach borrows information across types but also incorporates "clusters" of types, simultaneously enabling strong borrowing across similar-performing types and almost no borrowing for outlying types.

We apply a Bayesian Clustered Hierarchical Model in the context of a phase II registration-focused clinical trial investigating a targeted therapy for tumors having a particular molecular target across 9 rare cancers. A traditional statistical approach would be impossible due to the extreme rarity of each tumor by biomarker subtype. The trial involves all available subjects accrued over a fixed time period. The approach provides acceptable operating characteristics including controlling type I errors.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home