Abstract Details
Activity Number:
|
635
|
Type:
|
Topic Contributed
|
Date/Time:
|
Thursday, August 13, 2015 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract #315117
|
|
Title:
|
A Unified Family of Covariate-Adjusted Response-Adaptive Designs Based on Efficiency and Ethics
|
Author(s):
|
Jianhua Hu and Hongjian Zhu* and Feifang Hu
|
Companies:
|
MD Anderson Cancer Center and The University of Texas School of Public Health and The George Washington University
|
Keywords:
|
Asymptotic properties ;
clinical trial ;
generalized linear models ;
personalized medicine ;
power ;
response-adaptive randomization
|
Abstract:
|
Response-adaptive designs are desirable because of its advantages in efficiency and medical ethics. Covariate information plays an important role in both design and analysis of clinical trials for personalized medicine. A challenge is how to incorporate covariate information in response-adaptive designs while considering issues of both efficiency and medical ethics. To address this problem, we propose a new and unified family of covariate-adjusted response-adaptive designs based on two general measurements of efficiency and ethics. In this talk, we will discuss the important properties of the proposed procedures.
|
Authors who are presenting talks have a * after their name.
Back to the full JSM 2015 program
|
For program information, contact the JSM Registration Department or phone (888) 231-3473.
For Professional Development information, contact the Education Department.
The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
2015 JSM Online Program Home
ASA Meetings Department
732 North Washington Street, Alexandria, VA 22314
(703) 684-1221 • meetings@amstat.org
Copyright © American Statistical Association.