Analysis of Gene-Environment Interactions Using Shared Genetic Controls

• Activity Number: 107
• Type: Invited
• Date/Time: Monday, August 10, 2015 : 8:30 AM to 10:20 AM
• Sponsor: Biometrics Section
• Author(s): Yi-Hau Chen*
• Companies: Academia Sinica
• Keywords: case-control ; case-parent trio

Abstract

One of the greatest challenges in genetic studies is the determination of gene-environment interactions due to underlying complications and inadequate statistical power. With the increased sample size gained by using case-parent trios and unrelated cases and controls, the performance may be much improved. We propose a logistic regression framework model, based on the combined haplotype relative risk (CHRR) method, which intuitively pools the case-parent trios and unrelated subjects in a two by two table. Adjustment for covariates is straightforward in this method. We show through simulations the nice performance of the proposed method under various genetic models.