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Activity Number: 105
Type: Invited
Date/Time: Monday, August 10, 2015 : 8:30 AM to 10:20 AM
Sponsor: IMS
Abstract #314367
Title: Gene Coexpression Measures in Large Heterogeneous Samples Using Count Statistics
Author(s): Y.X. Rachel Wang and Michael Waterman and Haiyan Huang*
Companies: UC Berkeley and University of Southern California and UC Berkeley
Keywords: local rank patterns ; bivariate association ; random permutation statistics ; Stein's approximation
Abstract:

With the advent of high-throughput technologies making large-scale gene expression data readily available, developing appropriate computational tools to process these data and distill insights into systems biology has been an important part of the "big data" challenge. Gene coexpression is one of the earliest techniques developed that is still widely in use for functional annotation, pathway analysis, and, most importantly, the reconstruction of gene regulatory networks, based on gene expression data. However, most coexpression measures do not specifically account for local features in expression profiles. For example, it is very likely that the patterns of gene association may change or only exist in a subset of the samples, especially when the samples are pooled from a range of experiments. We propose two new gene coexpression statistics based on counting local patterns of gene expression ranks to take into account the potentially diverse nature of gene interactions. In particular, one of our statistics is designed for time-course data with local dependence structures, such as time series coupled over a subregion of the time domain. We provide asymptotic analysis of their distrib


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