JSM 2015 Preliminary Program

Online Program Home
My Program

Abstract Details

Activity Number: 103
Type: Invited
Date/Time: Monday, August 10, 2015 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract #314352 View Presentation
Title: A Principal Stratification Approach to Receipt of Rescue Medication in Early Escape Designs
Author(s): David Watson*
Companies: Carleton College
Keywords: Bayesian methods ; placebo-controlled trials ; Rubin causal model
Abstract:

Early escape designs were developed as a modification of placebo-controlled clinical trials in order to reduce the length of time subjects remain on an assigned treatment under which they appear to be deteriorating, and instead receive additional rescue medication. Although early escape designs alleviate ethical concerns, they lead to complications with statistical analysis and interpretation. Comparisons between the groups assigned to different treatments are no longer interpretable as simple comparisons of received treatments because the treatment actually received may have changed from that assigned. Receipt of rescue medication is a post-treatment outcome that might also affect clinically relevant outcomes. We approach this problem with the principal stratification framework, in which subjects belong to latent groups based on post-treatment variables, here, receipt of rescue medication. For only one principal stratum can the estimands of causal effects of assignment be interpreted as the causal effect of receipt of active treatment versus placebo. We present the results from a placebo-controlled clinical trial of treatment for relapsing-remitting multiple sclerosis in order to


Authors who are presenting talks have a * after their name.

Back to the full JSM 2015 program





For program information, contact the JSM Registration Department or phone (888) 231-3473.

For Professional Development information, contact the Education Department.

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

2015 JSM Online Program Home