Influence of the Risk Factors in the Survival Expectation of Nonmestastatic Breast Cancer Patients

• Activity Number: 333
• Type: Contributed
• Date/Time: Tuesday, August 5, 2014 : 10:30 AM to 12:20 PM
• Sponsor: Biometrics Section
• Author(s): Luis Cid-Serrano*+ and Marcela Valdes and Chyntia Fuentes
• Companies: UBB and Universidad del Desarrollo and Universidad de Concepcion
• Keywords: breast cancer ; survival function ; risk factors

Abstract

A sample of 1200 breast cancer patients with complete follow of 25 years, was studied to assess the effect of the risk factors of acquiring the disease over the survival expectation. Risk factors included were age of the patient at diagnostic, and at first child birth, lactation, menarche, menopause, family history of breast cancer, among others. Several survival estimators were used, including Kaplan and Meier´s product limit estimator and median and quartiles residual life time. Cox´s proportional hazards regression was used to estimate the effect of tumor and disease characterization, including size of the tumor, and differential temperature respect to the healthy breast, estimated through infrared imaging. A first analysis showed that patients at stage IV of the disease had completely different response, due to the presence of metastasis, which overcame any other possibly influencing factor. Hence the analysis of the effect of risk factors was performed only for patients at stage I, II and III. The results showed, for example, that early age at first child birth, being a protection factor, it also acts protectively, providing better survival expectations to those women.