Abstract Details
Activity Number:
|
407
|
Type:
|
Topic Contributed
|
Date/Time:
|
Tuesday, August 6, 2013 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #309851 |
Title:
|
Improving Median Progression-Free Survival Methods Through Design or Analysis
|
Author(s):
|
Keaven Anderson*+ and Honghong Zhou
|
Companies:
|
Merck Research Laboratories and Merck Research Laboratories
|
Keywords:
|
progression free survival ;
clinical trials ;
survival
|
Abstract:
|
Median duration of progression free survival is often forms a crucial component in the comparison of two cancer regimens when trying to evaluate the benefit provided by a new treatment. Unfortunately, progression, the main component of this endpoint, is only assessed on a periodic basis which can lead to an unstable estimate of the difference in treatment group medians. We explore the value of adding progression evaluations or randomizing patients to non-overlapping schedules. We also explore the ability of parametric and nonparametric interval-censoring methods to improve estimation. A randomized scan schedule appears helpful in improving median comparisons.
|
Authors who are presenting talks have a * after their name.
Back to the full JSM 2013 program
|
2013 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.
The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Copyright © American Statistical Association.