Abstract Details
Activity Number:
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536
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Type:
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Contributed
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Date/Time:
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Wednesday, August 7, 2013 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #309519 |
Title:
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Negative Binomial Models for Two Period Cross-Over Trials Involving Overdispersed Count Data
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Author(s):
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Mallikarjuna Rettiganti*+ and Haikady Nagaraja
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Companies:
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University of Arkansas for Medical Sciences and The Ohio State University
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Keywords:
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Crossover trial ;
Negative Binomial ;
Overdispersion ;
Sample size ;
Power analysis
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Abstract:
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Crossover trials are quite common in clinical trials and methods for analyzing count data from cross-over trials are well documented assuming the Poisson distribution provides a reasonable fit. However, such count data are generally overdispersed and the negative binomial (NB) distribution is used as an alternative. We model count data from crossover trials using a NB distribution and examine likelihood based parametric tests such as likelihood ratio test, Rao's score test, Wald tests as well as nonparametric alternatives to test for the treatment effect. We compare the Type I error rates and power of these tests using simulation and propose the best tests under different parametric scenarios. Robustness of these tests to violations of distributional assumptions and parametric assumptions will be investigated and suitable tests will be advocated.
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Authors who are presenting talks have a * after their name.
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