The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Online Program Home
Abstract Details
Activity Number:
|
499
|
Type:
|
Topic Contributed
|
Date/Time:
|
Wednesday, August 1, 2012 : 10:30 AM to 12:20 PM
|
Sponsor:
|
WNAR
|
Abstract - #304744 |
Title:
|
Estimating Mixture Components from Qqplots: Gene Expression Vectors in Beetles
|
Author(s):
|
Karen Kafadar*+
|
Companies:
|
Indiana University
|
Address:
|
Dept. of Statistics, Bloomington, IN, ,
|
Keywords:
|
empirical null ;
local false discovery rate ;
QQ plot ;
microarray experiment ;
experimental design
|
Abstract:
|
Gene expressions (Log-transformed) typically are assumed to come from a mixture of two Gaussian distributions, with means zero and nonzero (cf. Efron, p.18, (2.11)), or sometimes three means (zero, negative = under-expressed, positive = over-expressed). The "empirical null" can be estimated via "central matching" (cf. Efron, p.99). Alternatively, we propose a method based on the conventional QQ plot. We illustrate the inferences using FDR and local FDR on data from a microarray experiment involving beetles of 16 types. The results indicate genes responsive to tissues, gender, nutrition status, and combinations of factors.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2012 program
|
2012 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.