The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
307
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Tuesday, August 2, 2011 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #303230 |
|
Title:
|
Multiple Endpoints With Latent Variable Approach
|
|
Author(s):
|
Juanmei Liu *+ and Minglei Liu
|
|
Companies:
|
Medtronic Inc. and Medtronic Inc.
|
|
Address:
|
, , 94086, USA
|
|
Keywords:
|
multiplicity ;
multiple endpooints ;
latent variable ;
correlation structure ;
polychoric correlation
|
|
Abstract:
|
Traditional approaches dealing with multiplicity from multiple endpoints are in the form of p-value adjustment.These approaches will not take in account the possible latent structure of the multiple endpoints and may have lower power. To gain power, we developed latent variable approach in theory by considering correlation/covariance structure of the multiple outcomes. With reduced dimension, no adjustment of p values or only less adjustment are required. We developed conditions under which this approach is applied and we generalized this method to incorporate all types of endpoints. A simulation study is presented and an example from real clinical trial data is analyzed and interpreted.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.