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Abstract Details
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Activity Number:
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350
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Type:
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Contributed
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Date/Time:
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Tuesday, August 2, 2011 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #302786 |
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Title:
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A Comparison of Covariate-Adaptive Randomization Procedures in Clinical Trials
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Author(s):
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Dan Neal and Tamekia Jones and Jivan Ginosian and Samuel S. Wu*+
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Companies:
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University of Florida and University of Florida and Bioness Inc. and University of Florida
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Address:
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Department of Biostatistics, Gainesville, FL, 32601,
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Keywords:
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adaptive-covariate randomization ;
clinical trial design ;
Wei's urn ;
Pocock-Simon
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Abstract:
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When there are many important covariates or prognostic factors in a clinical trial, stratified randomization becomes infeasible. To ensure balance over the covariates, several authors have proposed covariate-adaptive randomization procedures, which are especially appealing when there are pre-planned subgroup analyses involving the covariates. In this talk, we will compare Zelen's rule, the Pocock-Simon procedure, Wei's marginal urn design and other methods on their balancing properties and predictability of assignment. The results will be illustrated using a real randomized controlled trial that was conducted to determine the effectiveness of electrical stimulation therapy in chronic post-stroke subjects.
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Authors who are presenting talks have a * after their name.
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