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Abstract Details
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Activity Number:
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178
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Type:
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Contributed
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Date/Time:
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Monday, August 1, 2011 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #302422 |
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Title:
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A Practical Guide to Drug Combination Models
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Author(s):
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Wei Zhao*+ and Lanju Zhang and Lingmin Zeng and Harry Yang
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Companies:
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MedImmune, Inc. and MedImmune, Inc. and MedImmune, Inc. and MedImmune, Inc.
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Address:
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1 MEDIMMUNE WAY, GAITHERSBURG, MD, 20878,
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Keywords:
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Abstract:
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Combination of drugs becomes more promising, especially in treating malignant cancers. Scientists are interested in identifying compounds that act synergistically when combined. There are many statistical methods proposed to estimate the combination index and to construct its confidence interval in the literature. Also made available are statistical software packages for evaluations of combination therapies. With extensive practical experiences in application of different models and statistical packages, we have modified some of the packages to make them both more user-friendly and robust under unconventional conditions. In this presentation, we will compare and demonstrate the strength and weakness of different methods and software packages.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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