The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
Activity Number:
|
177
|
Type:
|
Contributed
|
Date/Time:
|
Monday, August 1, 2011 : 10:30 AM to 12:20 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #302195 |
Title:
|
Measurement Error on Cost-Effectiveness Ratio and Net Benefit
|
Author(s):
|
Ruifeng Xu*+ and Ping-Shou Zhong and John R. Cook
|
Companies:
|
Merck Research Laboratories and Iowa State University and Merck Research Laboratories
|
Address:
|
Mail Stop 1C-60, North Wales, PA, 19454,
|
Keywords:
|
measurement error ;
cost-effectiveness ;
net benefit
|
Abstract:
|
Measurement error on cost-effectiveness analysis has received increasingly attention in the pharmaceutical industry. In this presentation, we explore the influence of measurement error on the cost-effectiveness ratio and net benefit. We found that the measurement error on the biomarker could induce sufficient large bias in the estimation of cost-effectiveness ratio. A deconvolution method and Simulation Extrapolation method are proposed to correct the bias. The asymptotic normalities of the new estimators are derived. In the second part, a realistic modeling method, multi-cycle patient level simulation model is explored to assess the impact of measurement error on the cost-effectiveness ratio and net benefit. Our results show that the measurement error could underestimate the net benefit and overestimate the cost-effectiveness ratio.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.