The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
Activity Number:
|
666
|
Type:
|
Contributed
|
Date/Time:
|
Thursday, August 4, 2011 : 10:30 AM to 12:20 PM
|
Sponsor:
|
Section on Health Policy Statistics
|
Abstract - #302082 |
Title:
|
A New Approach to Futility Stopping in Clinical Trials
|
Author(s):
|
Pei He*+ and Tze Leung Lai and Olivia Yuehwen
|
Companies:
|
Stanford University and Stanford University and Stanford University
|
Address:
|
345 Sheridan Ave. Apt. 108, Palo Alto, CA, 94306,
|
Keywords:
|
sequential design ;
futility stopping ;
survival analysis ;
clinical trials
|
Abstract:
|
Early stopping due to futility, or go/no-go decisions, during interim analysis has become an important feature of clinical trial designs. Current methods for futility stopping in the literature are mostly based on conditional power or predictive power in conjunction with the theory of stochastic curtailment or group sequential design. They have certain drawbacks, especially when the test statistics are nonparametric or when the trial involves survival data that are monitored at pre-specified calendar times. Herein we introduce a new approach to futility stopping in clinical trial designs that can overcome these difficulties. Simulation studies and theoretical analysis show that the method developed is nearly optimal in both parametric and nonparametric problems. Moreover, due to its flexibility, the approach can circumvent the difficulties of "information time" versus "calendar time" in time-sequential clinical trials to compare the failure times of two treatments.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.