JSM 2011 Online Program

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Abstract Details

Activity Number: 517
Type: Contributed
Date/Time: Wednesday, August 3, 2011 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #302009
Title: Software Applications to Group Sequential Trial Design and Monitoring
Author(s): Li Zhu*+ and Liyun Ni and Bin Yao
Companies: Amgen Inc. and Amgen Inc. and Amgen Inc.
Address: One Amgen Center Drive, Mail Stop 24-2-A, Thousand Oaks, CA, 91320,
Keywords: Conditional power ; Error spending function ; Interim monitoring ; Stopping boundary
Abstract:

Group sequential methods are commonly used in clinical trials as they allow valid inference when statistical tests are performed on accumulating data from ongoing trials. Several software applications have become available to meet the computational need for group sequential trial design and monitoring. This talk will review several up-to-date software applications. The capabilities and special features of the software applications are illustrated and compared through practical examples.


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