JSM 2011 Online Program

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Abstract Details

Activity Number: 307
Type: Contributed
Date/Time: Tuesday, August 2, 2011 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #301071
Title: Selecting the Superior Dose After an Interim Analysis Taking into Consideration Type I Error and Power Configuration
Author(s): Haifeng Zhang*+
Companies: University of Toledo
Address: , , ,
Keywords: Conditional Power ; Type I error ; interim analysis
Abstract:

This presentation focuses on multiple dose comparisons with a control for the purpose of identifying at least one dose which is superior to a comparator. An interim analysis can be used to drop dose(s) that are found to be either inferior or having little chance to show a statistically significant superiority to the comparator. We study the type-one error and power of various design configurations and propose a strategy for such an analysis.


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