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Abstract Details
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Activity Number:
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339
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 2, 2011 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #300949 |
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Title:
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The Effect of Periodic Follow-Up: Design and Analysis of Progression-Free Survival Data
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Author(s):
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Zhigang Zhang*+
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Companies:
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MSKCC
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Address:
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307 E. 63rd Street, New York, NY, 10065,
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Keywords:
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Clinical Trials ;
Progression-Free Survival ;
Interval Censoring
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Abstract:
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In clinical trials, progression-free survival (PFS) is often used as an endpoint to assess the efficacy of a therapy. In contrast to overall survival (OS), it is not affected by the second-line therapy and can be observed earlier. However, the measurement of PFS can be difficult both clinically and statistically. As a matter of fact, its accuracy highly depends on interpretation from the radiologists and timing of the scheduled follow-up examinations. The latter is known as interval censoring in biostatistics. In this talk, I will focus on this aspect and discuss issues in experimental design and statistical analysis of PFS. I will present some simulation studies and real data analysis results to illustrate my points.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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