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Abstract Details
Activity Number:
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444
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Type:
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Invited
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Date/Time:
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Wednesday, August 3, 2011 : 8:30 AM to 10:20 AM
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Sponsor:
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ENAR
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Abstract - #300429 |
Title:
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Methods for Clustered Encouragement Design Studies with Missing Data
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Author(s):
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Leslie Taylor*+ and Xiao-Hua "Andrew" Zhou
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Companies:
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VA Puget Sound Health Services R&D and University of Washington
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Address:
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1100 Olive Way, Suite 1400 , Seattle, WA, 98101,
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Keywords:
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causal inference ;
clustered encouragement design ;
complier average causal effect ;
missing data ;
multiple imputation ;
principal stratification
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Abstract:
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Encouragement design studies are particularly useful for estimating the effect of an intervention that cannot itself be randomly administered to some and not to others. They require a randomly selected group receive extra encouragement to undertake the treatment of interest, where the encouragement typically takes the form of additional information or incentives. We consider a "clustered encouragement design" (CED), where the randomization is at the level of the clusters (e.g. physicians), but the compliance with assignment is at the level of the units (e.g. patients) within clusters. Noncompliance and missing data are particular problems in encouragement design studies, where encouragement to take the treatment, rather than the treatment itself, is randomized. The motivating study looks at whether computer-based care suggestions can improve patient outcomes in veterans with chronic heart failure. Since physician adherence has been inadequate, the original study focused on methods to improve physician adherence, although an equally important question is whether physician adherence improves patient outcomes. Here, we reanalyze the data to determine the effect of physician adherence.
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