This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Activity Details

514 * Wed, 8/4/2010, 10:30 AM - 12:20 PM CC-202 (West)
Dose Finding/Dose Response — Contributed Papers
Biopharmaceutical Section , Section on Risk Analysis
Chair(s): Charles David Kincaid, COMSYS Clinical
10:35 AM Key Considerations for Simulations to Optimize Dose-Finding Trials — Natalie Cheung Hall, Eli Lilly and Company
10:50 AM Stopping Rules for Bayesian Dose-Finding Oncology Trials — Yanqiong Zhang, Sanofi-Aventis ; Yi He, sanofi-aventis ; Guillaume Marchand, sanofi-aventis ; Pierre Mancini, sanofi-aventis ; Sandrine Micallef, sanofi-aventis
11:05 AM A Statistical Design for Investigating Skin Diffusion-Based Dose Response in Humans — Jihao Zhou, Allergan Pharmaceuticals, Inc. ; Thomas Lin, Allergan Pharmaceuticals, Inc. ; Susan Guo, Allergan Pharmaceuticals, Inc. ; Barbara Scholz, Allergan Pharmaceuticals, Inc.
11:20 AM Comparison of Meta-Analytic Methods That Combine Direct and Indirect Evidence to Assess Dose Relationship — Qi Zhang, Eli Lilly and Company ; Mary Nilsson, Eli Lilly and Company ; Yoko Tanaka, Eli Lilly and Company ; Brenda Crowe, Eli Lilly and Company ; Xiaobi Huang, University of Michigan
11:35 AM A Dose-Finding Method in Joint Modeling of Efficacy and Safety: An Extension of the MCP-Mod Method — Aiyang Tao, Novartis ; Yong Lin, University of Medicine and Dentistry of New Jersey ; Jose Carlos Pinheiro, Johnson & Johnson ; Weichung J. Shih, University of Medicine and Dentistry of New Jersey
11:50 AM Dose-Escalation Approaches for Two Agents in Early-Phase Oncology Studies — Yevgen Tymofyeyev, Merck & Co., Inc. ; Christine K. Gause, Merck Research Laboratories ; Keaven M. Anderson, Merck Research Laboratories
12:05 PM A Closed Testing Procedure Based on Ordered Alternatives in Dose-Response Studies — Girish Aras, Amgen Inc. ; Juan Li, Amgen Inc.



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