This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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187
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Type:
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Contributed
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Date/Time:
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Monday, August 2, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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Abstract - #309409 |
Title:
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Trait Well-Being Predicts Placebo Response in Healthy Controls
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Author(s):
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Hamdan Azhar*+ and Christian Stohler and Jon-Kar Zubieta
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Companies:
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University of Michigan and University of Maryland and University of Michigan
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Address:
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, , ,
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Keywords:
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placebo effect ;
neuroimaging ;
psychology ;
PLS regression
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Abstract:
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The present study documents for the first time the relationship between general trait well-being and placebo response. Thirty-eight healthy young volunteers with no prior history of psychiatric illness or substance abuse completed personality questionnaires and underwent a 20-minute standardized pain challenge both in the absence and presence of a placebo with expected analgesic properties. Pain intensity was rated every 15 seconds on a scale of 0 to 100 and the percent difference in mean pain rating was defined as the primary outcome measure. Partial least squares regression (PLS) with leave-one-out cross-validation revealed a consistent effect of trait well-being in predicting placebo response. The overall variance explained by the model was nearly 30%, providing significant evidence of trait and state effects on placebo response.
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