This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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30
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Type:
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Contributed
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Date/Time:
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Sunday, August 1, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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Abstract - #309405 |
Title:
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Is It Rare or Common? A Coalescent Tree Approach to Identify the Genetic Types of Variants Underlying Complex Diseases
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Author(s):
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Kaustubh Adhikari*+ and Christoph Lange
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Companies:
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Harvard University and Harvard School of Public Health
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Address:
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56 Calumet St., Boston, MA, 02120,
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Keywords:
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Complex Diseases ;
Rare Variants ;
Common Variants ;
Ancestral Recombination Graphs ;
Coalescent Trees ;
Bayesian Modeling
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Abstract:
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An important problem in modern genetic studies is whether a given disease is caused by a few common variants or by several rare variants in a gene. This paper presents a unique method of identifying the type of variants responsible for a disease in a gene segment through SNP genotyping. Based on case-control data of SNP genotypes in a gene segment, we obtain joint posterior distribution of the number of common and rare variants present in the segment (phenocopy allowed). We do a Bayesian modeling using coalescent genealogical trees to model the unknown ancestral history of both the cases and the controls jointly. This method, applied to a candidate-gene segment observed in a COPD study, utilizes the ability of minARGs (Ancestral Recombination Graphs) to model the ancestral structural history (with mutation and recombination) by employing the information present in the SNP markers.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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