This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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253
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Type:
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Contributed
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Date/Time:
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Monday, August 2, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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Abstract - #309145 |
Title:
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Estimating Incremental Value in Marker Combinations Using a Two-Stage Study Design
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Author(s):
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Aasthaa Bansal*+ and Margaret Sullivan Pepe
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Companies:
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University of Washington and Fred Hutchinson Cancer Research Center
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Address:
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Department of Biostatistics, Seattle, WA, 98195,
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Keywords:
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two-stage design ;
diagnostic tests ;
classification ;
biomarkers ;
ROC
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Abstract:
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BACKGROUND: When an existing marker, X, does not have sufficient diagnostic accuracy on its own, a new marker, Y, may in combination with X improve performance. We investigate estimating the increment in ROC performance due to Y from a two-stage study with X measured for all subjects in a cohort and Y measured for a case-control subset. METHODS: We develop non-parametric and semi-parametric methods for estimation and evaluate the methodology using simulation studies. RESULTS: The methods are easy to implement and provide valid inference. Matching controls to cases can compromise estimation of incremental value in certain settings. Using a combination of matched and unmatched controls may provide a more efficient approach to estimation in such instances.
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Authors who are presenting talks have a * after their name.
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