This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
72
|
Type:
|
Contributed
|
Date/Time:
|
Sunday, August 1, 2010 : 4:00 PM to 5:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #309144 |
Title:
|
Interval-Censored Time-to-Event Data in Clinical Trials: Analyzing and Designing
|
Author(s):
|
Xing Sun*+ and Cong Chen
|
Companies:
|
Merck & Co., Inc. and Merck & Co., Inc.
|
Address:
|
, , ,
|
Keywords:
|
clinical trial ;
survival analysis ;
interval-censored ;
group sequential design
|
Abstract:
|
Interval-censored time-to-event data occur frequently in randomized clinical trials. These data often pose challenges for both trial design and statistical analysis. Standard methods, generally accepted and practiced by pharmaceutical industry, are often simple imputation based methods. In this study, we demostrate by simulation that under typical clinical trial settings, these simple methods are less optimal than other more sophisticated nonparametric likelihood based methods proposed two decades ago. Also, unlike for right-censored survival data, expected sample size/power depends heavily on baseline survival distribution and interval frequency for interval-censored data. A discussion on how to design a trial with interval censored data to accommodate this property, especially for group sequential design, will also be included.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.