This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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283
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #309047 |
Title:
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Joint Analysis of Symptom and Progression-Free Survival Endpoints in Previously Treated Malignant Pleural Mesothelioma
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Author(s):
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Michelle D. Hackshaw+ and Mark E. Boye* and Teena M. West and Angela W. Prehn and Wei Shen and Luping Zhao
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Companies:
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Walden University and Eli Lilly and Company and Eli Lilly and Company and Walden University and Eli Lilly and Company and Eli Lilly and Company
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Address:
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155 Fifth Avenue South, Minneapolis, MN, 55401, USA
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Keywords:
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mesothelioma ;
survival ;
patient-reported outcomes ;
joint models
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Abstract:
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BACKGROUND: Traditionally survival and patient-reported outcome (PRO) endpoints have been analyzed separately. Novel techniques are now available to jointly estimate the association between longitudinal changes in PRO measures and survival.
METHODS: We conducted post-hoc analyses of PFS and PRO data from a phase III study of best supportive care (BSC) versus pemetrexed-plus-BSC (pem) in patients treated with second-line therapy for advanced MPM. In the original study, PFS was a secondary end point and PROs were measured using the Lung Cancer Symptom Scale. Statistical methods included use of latent growth curve models (LGCMs) and survival models.
RESULTS/CONCLUSIONS: These novel methods allowed us to validate that worsening of MPM symptoms (PROs) was related to an increase in rate of disease progression, and may help support the use of PFS as an endpoint in oncology clinical trial
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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