This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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513
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Type:
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Contributed
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Date/Time:
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Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #308997 |
Title:
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Statistical Modeling of the Duration of Protection of Postvaccination Antibody
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Author(s):
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Jason Martin*+ and Stephanie Klopfer
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Companies:
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Merck & Co., Inc. and Merck & Co., Inc.
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Address:
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351 Sumneytown Pike, North Wales, PA, 19454, USA
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Keywords:
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Vaccine ;
Persistence ;
Exponential ;
Decay ;
Extrapolation ;
Modeling
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Abstract:
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Clinical studies supporting the licensure of a new vaccine typically only measure the vaccine's effect for a few months to a few years after vaccination. However, of interest to public health experts and vaccine policy makers is the long-term duration of protection from disease after vaccination. Various statistical models were evaluated to extrapolate the long-term persistence and duration of detectable antibody after receipt of hepatitis vaccine based on shorter-term data. Historically, exponential decay models have been used to assess long-term hepatitis antibody persistence using observed persistence data up to 3 years postvaccination. The current investigation updates these historical models with observed data up to 10 years postvaccination, as well as evaluates additional extrapolation models based on mixed effects and piece-wise mixed effects models and a power law model.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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