This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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626
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Type:
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Contributed
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Date/Time:
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Thursday, August 5, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #308843 |
Title:
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Sample Size Re-estimation for a Time-to-event Endpoint Based on Stratified Analysis
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Author(s):
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Liang Chen*+
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Companies:
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Pfizer Inc.
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Address:
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219 E. 42nd St., New York, NY, 10017,
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Keywords:
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Sample Size Re-estimation ;
Time-to-event Endpoint ;
Conditional Power ;
Stratified Analysis
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Abstract:
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When calculating conditional power for sample size re-estimation at an interim analysis, the test statistic for the final analysis can be for a non-stratified analysis or for a stratified analysis. This paper discussed the method for the situation where stratified analysis is more appropriate for sample size re-estimation at an interim analysis. We have applied this method to a randomized phase 3 trial for the adjuvant treatment of a solid tumor cancer comparing an experimental drug with placebo.
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Authors who are presenting talks have a * after their name.
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