This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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78
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Type:
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Contributed
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Date/Time:
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Sunday, August 1, 2010 : 4:00 PM to 5:50 PM
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Sponsor:
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Section on Risk Analysis
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Abstract - #308757 |
Title:
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Optimal Designs for Toxicology Studies with Multiple Responses and Multiple Stressors
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Author(s):
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Edward L. Boone*+ and David Edwards and Shuchi Jain
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Companies:
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Virginia Commonwealth University and Virginia Commonwealth University and Virginia Commonwealth University
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Address:
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Department of Statistics and Operations Research, Richmond , VA, 23284,
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Keywords:
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Risk Analysis ;
Design of Experiments ;
Dose-Response ;
Toxicology
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Abstract:
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Toxicologists are often confronted with studies in with multiple stressors and multiple responses. Using a multivariate dose-response approach allows for the analysis of the study data. However, this work presents a two stage approach to determining the best second stage study design for this situation. Two optimality criterion will be introduced which are unique to this problem: Minimum Bench Mark Dose Tolerable Region (BMDTR) area variance and Minimum BMDTR mixture ray variance. We present both a simulated dataset and a real dataset and use each of the above criteria to suggest augmented optimal designs for the second stage.
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