This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
129
|
Type:
|
Contributed
|
Date/Time:
|
Monday, August 2, 2010 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #308665 |
Title:
|
Relative Power and Robustness of Mixed Model, GEE, and MMRM Analysis of Alzheimer's Disease Treatment Trials
|
Author(s):
|
Steven D. Edland*+
|
Companies:
|
University of California, San Diego
|
Address:
|
9500 Gilman Dr, La Jolla, CA, 98092,
|
Keywords:
|
Clinical Trial ;
Power ;
Random Effects Model ;
Mixed Effects Model ;
GEE ;
MMRM
|
Abstract:
|
The group by time term in a mixed effects regression analysis with random slopes and intercepts can be used to test for differences in mean rate of progression of quantitative trait outcome measures in clinical trials comparing treatment versus control. Alternative analyses include covariance structure robust marginal models with estimation by generalized estimating equations (GEE) and model robust mixed model repeated measures (MMRM) analysis of change scores. We use derivations and Monte Carlo simulations informed by extensive placebo arm data from completed trials performed by the Alzheimer's Disease Cooperative Study to characterize the relative power and bias of these methods under a range of plausible models and study subject dropout rates.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.