This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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16
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Type:
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Topic Contributed
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Date/Time:
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Sunday, August 1, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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Abstract - #308656 |
Title:
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Investigation of Maternal Effects, Maternal-Foetal Interactions, and Parent-of-Origin Effects (Imprinting) Using Mothers and Their Offspring
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Author(s):
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Heather Jane Cordell*+
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Companies:
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Newcastle University
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Address:
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Institute of Human Genetics, Newcastle upon Tyne, International, NE1 3BZ, UK
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Keywords:
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genetics ;
imprinting ;
case/parent trio ;
mother ;
father ;
offspring
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Abstract:
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A popular design for the investigation of complex genetic effects, including parent-of-origin (imprinting) effects, effects of maternal genotype and maternal-foetal interactions, is to collect DNA from affected offspring and their mothers. I describe a multinomial modelling approach that allows the estimation of complex genetic effects of this type using data from either case/mother duos or case/parent trios. Through the incorporation of additional assumptions (such as Hardy-Weinberg equilibrium, random mating and known allele frequencies) and/or the incorporation of additional control samples, I show that the parameters of interest are identifiable and well-estimated by our method. I investigate the required sample sizes and data structures necessary to provide accurate estimation of such effects and high power for their detection.
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Authors who are presenting talks have a * after their name.
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