This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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130
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Type:
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Contributed
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Date/Time:
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Monday, August 2, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308551 |
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Title:
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Conditional Power and Predictive Power Approaches to Interim Monitoring in Equivalence Trials
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Author(s):
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Xiaojiang Zhan*+
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Companies:
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Merck & Co., Inc.
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Address:
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, , ,
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Keywords:
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Clinical trials ;
Interim analysis ;
Predictive inference ;
Two one-sided tests (TOST) ;
Brownian motion
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Abstract:
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Conditional power (frequentist) and predictive power (mixed Bayesian-frequentist) approaches have been proposed in the literature for interim monitoring of superiority clinical trials. With these stochastic curtailment methods, a decision to continue the trial or curtail sampling at an interim look is based on the probability of getting a statistically significant result at the end of the trial conditional on the data already observed. This talk extends these approaches to equivalence trials using the two one-sided tests (TOST) procedure.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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