This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
235
|
Type:
|
Contributed
|
Date/Time:
|
Monday, August 2, 2010 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Section on Statistics in Epidemiology
|
Abstract - #308543 |
Title:
|
Comparison of Methods for g X g Interaction for Quantitative Traits in Case-Control Association Studies
|
Author(s):
|
Raymond George Hoffmann*+ and Thomas J. Hoffmann and Pippa Simpson and Soumitra Ghosh
|
Companies:
|
Medical College of Wisconsin and University of California, San Francisco and Medical College of Wisconsin and Medical College of Wisconsin
|
Address:
|
QHS, Pediatrics, Milwaukee, WI, 53226,
|
Keywords:
|
gene by gene ;
genetic interaction ;
qtl ;
quantitative trait
|
Abstract:
|
Identifying g x g interaction for quantitative traits is a difficult problem because of the many potential forms for interaction. Multiple methods have been used to model these relationships: linear regression, survival analysis, Classification and Regression Trees (CART), Random Forests, etc. The goal of this study is to compare these methods for different types of interaction -- linear by linear, a PK/PD pharmocogenetic model, as well as some of the more complex forms found in genetics such as a positive interaction at one level and a negative interaction at another level. Simulations use the R system together with the R genetics, cart, randomForest ang rgenetics libraries.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.