This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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405
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Type:
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Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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Abstract - #308288 |
Title:
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Extension of Kaplan-Meier Methods in Longitudinal Observational Studies with Time-Varying Exposure
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Author(s):
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Stanley Xu*+ and Susan Shetterly and David Powers and Marsha Raebel and Michael Ho and Thomas Tsai and David Magid
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Companies:
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Kaiser Permanente Colorado and Kaiser Permanente Colorado and U.S. Census Bureau and Kaiser Permanente Colorado and Denver VA Medical Center and Denver VA Medical Center and Kaiser Permanente Colorado
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Address:
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10065 E. Harvard Ave, Denver, CO, 80237,
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Keywords:
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observational study ;
Kaplan Meier estimates ;
stabilized weights ;
time-varying exposure ;
drug eluting stents ;
inverse propensity score weighting
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Abstract:
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Stabilized weights have been developed to allow estimation of treatment effects and its variance directly from regression in the presence of confounders in observational studies. Generally Kaplan-Meier method ignores confounders and does not control for time-varying exposures. Recently the association of clopidogrel use with bleeding, myocardial infarction (MI) and death events was examined in 7689 patients with follow-up up to 18 months after receiving drug eluting stents. The mean clopidogrel-covered days was 257;stops and restarts of the medication were common. To compare the Kaplan-Meier estimates with time-varying exposure while adjusting for known confounding factors, we developed Kaplan-Meier like estimates with stabilized weights and developed test statistics. It was shown that clopidogrel use was associated with increased risk of bleeding and a decreased risk of MI or death.
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Authors who are presenting talks have a * after their name.
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