This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
281
|
Type:
|
Topic Contributed
|
Date/Time:
|
Tuesday, August 3, 2010 : 8:30 AM to 10:20 AM
|
Sponsor:
|
Section on Statistical Learning and Data Mining
|
Abstract - #308278 |
Title:
|
Inference of Biological Pathway from Gene Expression Profiles by Time Delay Boolean Networks
|
Author(s):
|
Tung-Hung Chueh and Henry Horng-Shing Lu*+
|
Companies:
|
National Chiao Tung University and National Chiao Tung University
|
Address:
|
Institute of Statistics, , , Taiwan
|
Keywords:
|
Boolean network ;
Boolean function ;
EM algorithm
|
Abstract:
|
It is crucial to make inference of genetic regulatory networks from gene expression profiles and protein interaction data for systems biology. This study develops a new approach to reconstruct time delay Boolean networks as a tool for exploring biological pathways. Specifically, we prove that O(log n) state transition pairs are sufficient and necessary to reconstruct the time delay Boolean network of n nodes with high accuracy if the number of input genes to each gene is bounded. In the inference strategy, we compare all pairs of input genes in those basic relationships by their corresponding p-scores for every output gene. Then, we combine those consistent relationships to reveal the most probable relationship. We implement this method on simulated and empirical yeast gene expression data sets. The results show that this proposed method is extensible for realistic networks.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.