This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 686
Type: Contributed
Date/Time: Thursday, August 5, 2010 : 10:30 AM to 12:20 PM
Sponsor: Social Statistics Section
Abstract - #308058
Title: Modeling the Impact of Neurocognitive Impairment on Occupational Functioning: An Application to Bipolar Disorder
Author(s): Vivian H. Shih*+ and Carrie E. Bearden and Michael Green and Catherine A. Sugar and Michael Gitlin and Altshuler L. Lori
Companies: University of California, Los Angeles School of Public Health and University of California, Los Angeles School of Medicine and University of California, Los Angeles School of Medicine and University of California, Los Angeles School of Public Health and University of California, Los Angeles School of Medicine and University of California, Los Angeles School of Medicine
Address: 21962 Yellowstone Lane, Lake Forest, CA, 92630,
Keywords: bipolar disorder ; cognitive functioning ; applied modeling ; dimension reduction
Abstract:

Neurocognitive impairment may persist in asymptomatic bipolar patients, preventing them from performing normal occupational functions. 79 bipolar patients completed a neurocognitive test battery and functional status questionnaire at baseline and were reevaluated similarly during subsequent visits. Factor analysis and multiple imputations were used to preprocess the data and reduce the number of predictors due to small sample size. We used logistic models to predict functional recovery using neurocognitive domains. Visual scanning, verbal working memory, and processing speed predicted baseline functional recovery. Longitudinal changes in neurocognitive skills also predicted long-term functional recovery. Bootstrapping confirmed the stability of the results. More complex models were considered to handle design-induced dropout patterns.


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