This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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452
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 4, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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Abstract - #307995 |
Title:
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A Genomewide Association Study for Determinants of Hyperlipidemia in Korean Population via Beyond-Single-SNP Analysis
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Author(s):
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Taesung Park*+ and Eunjin Lee and Kyunga Kim and Seungyeoun Lee
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Companies:
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Seoul National University and Seoul National University and Seoul National University and Sejong University
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Address:
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56-1 Shillim-Dong Kwanak-Gu, Seoul, 151-747, South Korea
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Keywords:
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GWAS ;
association study ;
gene-gene interaction ;
multipel genes
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Abstract:
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We conducted Genome-Wide Association Study of lipid-related traits such as Total cholesterol, High density lipoprotein cholesterol, Low density lipoprotein cholesterol and Triglycerides with 327,872 SNP markers to identify genotype-phenotype association for Korean population. Our study included 8800 participants from recruitment areas: Ansan and Ansung which are urban and rural areas in Korea, respectively. We first performed separate analysis for each recruitment areas and then performed combined analysis. We showed a simple addition of area into the regression model is not enough for adjustment. We discussed several methods for combined analysis and compare their pros and cons.
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