This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 502
Type: Topic Contributed
Date/Time: Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #307987
Title: Determining Differences in Functional Connectivity Using a Combined fMRI/DTI Analysis
Author(s): DuBois Bowman*+ and Shuo Chen and Gordana Derado
Companies: Emory University and Emory University and Emory University
Address: 1518 Clifton Road, N. E., Atlanta, GA, 30322,
Keywords: fMRI ; DTI ; connectivity ; network analysis ; clustering
Abstract:

There is strong interest in investigating functional connectivity (FC) of the human brain, which involves a search for correlations between fMRI measures of brain activity from spatially distinct regions. Many such associations between regional brain activity measures are mediated by structural connections along white matter fiber tracts, providing an opportunity to incorporate DTI information into statistical analyses. We develop a novel statistical method for determining FC, called anatomically-weighted FC (awFC), which combines functional information from fMRI and anatomical information from DTI. We demonstrate that our multimodal approach achieves superior accuracy to FC analyses based solely on fMRI data. We also present an inference framework for comparing awFC results between subgroups of subjects. We apply our methodology to data from a depression study.


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