This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
256
|
Type:
|
Contributed
|
Date/Time:
|
Monday, August 2, 2010 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #307972 |
Title:
|
Definition of a Responder in Clinical Trials for Alcohol Dependence
|
Author(s):
|
Yun-Fei Chen*+ and Xiwen Ma
|
Companies:
|
Eli Lilly and Company and University of Wisconsin-Madison
|
Address:
|
7438 Royal Oakland Dr., Indianapolis, IN, 46236,
|
Keywords:
|
Responder Analysis ;
Quantile Regression ;
Alcohol Dependence ;
COMBINE
|
Abstract:
|
Alcohol Dependence, is one of the leading causes of disability and mortality worldwide. Treatment for alcohol dependence varies for each individual and the investigation of the efficacy of pharmacotherapy is not always traightforward. While trial is conducted, the definition of a responder is not under consensus in the field. Current recommendation in allowing grace period to calcuate the percentage of patients without heavy drinking for the rest of the trial does not take into account of baseline difference. We propose an innovative framework of responder analysis using the change from baseline relationship of the primary end point and one major health outcome measure with quantile regression from COMBINE data. We provide not only a meaningful definition to a responder,but also the quantile regression approach could be generalized for the statistical analysis in the field.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.