This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
|
Activity Number:
|
409
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #307869 |
|
Title:
|
Compare Sensitivity of Multiple Measures in Discerning a Treatment Effect
|
|
Author(s):
|
Hongwei Wang*+ and Arvind K. Shah
|
|
Companies:
|
Merck & Co., Inc. and Merck Research Laboratories
|
|
Address:
|
RY34-A320, PO Box 2000, Rahway, NJ, 07065,
|
|
Keywords:
|
multiple criteria ;
sensitivity ;
pairwise comparison ;
bootstrap ;
correlated endpoints
|
|
Abstract:
|
Multiple measures usually exist to reflect a patient's response to treatment. They usually have different characteristics and are moderately to highly correlated. An effective evaluation of their sensitivity in discerning a treatment effect could result in a substantial reduction of sample size required for a clinical trial. This evaluation needs to take the effect size and correlation structure into account which can be estimated from either a one-step procedure of multivariate analysis or a two-step procedure based on bootstrap. Further, the pairwise comparison among the multiple measures introduces the multiplicity issue which can be controlled using less stringent to more stringent criteria. Practical recommendation are given based on a detailed case study of an actual clinical trial data pool.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.