This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
13
|
Type:
|
Topic Contributed
|
Date/Time:
|
Sunday, August 1, 2010 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #307696 |
Title:
|
Detecting and Correcting for Population Genetic Structure in Large-Scale Case-Control Association Studies
|
Author(s):
|
Ilana Belitskaya-Levy*+ and Iryna Lobach and Judith D. Goldberg
|
Companies:
|
New York University School of Medicine and New York University School of Medicine and New York University School of Medicine
|
Address:
|
650 First Avenue, Room 512, New York, NY, 10016, USA
|
Keywords:
|
population genetic structure ;
genetic association study ;
melanoma ;
population stratification ;
ancestry informative markers ;
disease susceptibility
|
Abstract:
|
Recent advances in genetics suggest that complex diseases, such as cancer, are likely to have a genetic component. Genetic case-control association studies can be used to identify disease susceptibility markers. One of the major difficulties in the analysis of genetic association studies is that variation in allele frequencies among populations of different ancestries can confound analysis. We propose a statistical approach for inferring population genetic structure using a panel of ancestry informative markers (AIMs). A unique feature of the proposed methodology is that it addresses the situation when some AIMs may in fact also be disease susceptibility markers. Performance of the proposed approach is demonstrated using simulation studies. The application of the proposed methodology to a melanoma case-control study is presented.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.