This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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360
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Type:
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Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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Abstract - #307615 |
Title:
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Design, Implementation, and Results for a Bayesian Adaptive Randomization Trial for Targeted Therapy in Lung Cancer
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Author(s):
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Suyu Liu*+ and J. Jack Lee
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Companies:
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MD Anderson Cancer Center and MD Anderson Cancer Center
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Address:
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1400 Pressler St., Houston, TX, 77030,
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Keywords:
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Bayesian adaptive design ;
clinical trial ;
hierachical Bayes model
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Abstract:
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The BATTLE trial applies response adaptive randomization (AR) to identify promising treatment agents for lung cancer patients. A hierarchical Bayes model is used to characterize disease control rates in four treatment arms by incorporating biomarkers. After an equal randomization phase, patients were adaptively randomized to treatments based on the posterior disease control rates. A web-based application has been developed to conduct this trial. We have successfully randomized 255 patients, characterized the treatment efficacy and identified the associated predictive markers. The adaptive randomization, however, did not work as well as we planned. We will report the lessons learned from running this innovative trials for personalizing medicine. Practical considerations for running a successful Bayesian adaptive trial will be given.
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Authors who are presenting talks have a * after their name.
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