This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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625
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Type:
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Contributed
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Date/Time:
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Thursday, August 5, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #307433 |
Title:
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How to Handle Placebo Data in Dosing Ranging Studies Using 2-by-2 Crossover Design
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Author(s):
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Xin Zhao*+
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Companies:
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Merck & Co., Inc.
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Address:
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, , ,
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Keywords:
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crossover design ;
linear mixed model ;
dose ranging studies
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Abstract:
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A classic dose ranging study will have multiple parallel arms for multiple doses of investigational drug and placebo. Recently, 2-by-2 crossover design start to be utilized in dose ranging studies to reduce patients cost by utilizing within-patient treatment comparisons. Specifically, a 2-by-2 crossover for each dose may be implemented and hence the study will have the same number of 2-by-2 crossovers (each crossover has 2 sequences) as the number of the doses investigated . This design will have a lot of placebo data. The talk will discuss how to handle these placebo data appropriately.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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