This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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409
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Type:
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Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307225 |
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Title:
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Multiple Testing Problems with General Logical Restrictions in Clinical Trials
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Author(s):
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Alex Dmitrienko*+ and Ajit C. Tamhane
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Companies:
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Eli Lilly and Company and Northwestern University
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Address:
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10913 West 144th St, Overland Park, KS, 66221, USA
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Keywords:
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Multiple comparisons ;
Type I error rate ;
Gatekeeping procedures ;
Clinical trials
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Abstract:
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In this presentation we discuss multiple testing problems with general logical restrictions arising in clinical trials. The mixture-based framework can be used to construct gatekeeping procedures that account for complex logical relationships among multiple null hypotheses. These gatekeeping procedures control the familywise error rate in the strong sense and enable trial sponsors to set up powerful procedures based on p-value-based tests (eg, Hochberg-type or Hommel-type tests) or parametric tests (eg, regular and step-down Dunnett tests). The general methodology is illustrated using clinical trials with multiple dose-placebo comparisons and patient populations as well as dose-placebo comparisons and noninferiority/superiority objectives.
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