This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
231
|
Type:
|
Topic Contributed
|
Date/Time:
|
Monday, August 2, 2010 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Section on Nonparametric Statistics
|
Abstract - #307025 |
Title:
|
Semiparametric Regression Approaches for Longitudinal Genetic Studies
|
Author(s):
|
Yuanjia Wang*+
|
Companies:
|
Columbia University
|
Address:
|
722 West 168th Street, Room 205, New York, NY, New York, NY, 10032,
|
Keywords:
|
Genome-wide association ;
penalized spline ;
quantitative trait locus
|
Abstract:
|
In family-based longitudinal genetic studies, investigators collect repeated measurements on a trait that changes with time along with genetic markers at specific genomic locations. Since measurements are nested within subjects and subjects are nested within families, both the subject-level and the measurement-level correlations must be taken into account in statistical analysis in order to achieve more accurate estimation. In this paper, we propose two classes of semiparametric models along with their statistical estimation and hypothesis testing procedures for longitudinal genetic studies. Penalized spline is employed to estimate the nonparametric functions in the models. We apply the proposed methods to examine age-specific effects of the genetic variants identified in a recent genome-wide association study on longitudinal measures of blood pressure in the Framingham Heart Study.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.