This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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115
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 2, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307022 |
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Title:
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Evaluating personalized treatment strategies: Subset analyses do not avoid the loss of power due to subgroups with no treatment effect
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Author(s):
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Werner Vach*+ and Rene dePont Christensen and Oke Gerke
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Companies:
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Institute of Medical Biometry and Medical Informatics and University of Southern Denmark and Odense University Hospital
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Address:
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University Medical Center Freiburg, Freiburg, International, D-79104, Germany
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Keywords:
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targeted agents ;
randomised clinical trial ;
personalized treatment ;
power ;
multiplicity
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Abstract:
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As any other new treatment strategy, also personalized treatment strategies have to demonstrate their benefit over the current standard treatment in randomized clinical trials. However, for some subgroups of patients the proposed strategy my offer no benefit, decreasing the power of the trial. In this paper we investigate, whether one can overcome this loss in power by systematically testing all subsets of patients for the existence of a treatment effect.
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