This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
332
|
Type:
|
Topic Contributed
|
Date/Time:
|
Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #306990 |
Title:
|
Adaptive Designs with Sensitive Subgroup Selection
|
Author(s):
|
Yan Daniel Zhao*+ and Alex Dmitrienko
|
Companies:
|
Eli Lilly and Company and Eli Lilly and Company
|
Address:
|
, , ,
|
Keywords:
|
Adaptive Design ;
Taylored Therapy ;
Multiple Testing ;
Subgroup Selection ;
Extended Fallback Test
|
Abstract:
|
In tailored therapies it is essential to select sensitive subgroups of patients who may benefit more from the study treatment than the overall population. In the design phase of the study several potential sensitive subgroups are pre-defined based on previous studies and knowledge. Then, the objective of the study under consideration is to confirm or disregard these subgroups at pre-specified interim analyses or end of the study. In this paper we apply an extended fallback procedure to control the type I error level. Such a procedure is more powerful than existing approaches. We illustrate our approach using an oncology example and the operating characteristics are examined via simulation studies.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.