This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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113
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 2, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #306928 |
Title:
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Meta-Analytic Approach to the Validation of Surrogate Endpoints: The Past Decade
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Author(s):
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Tomasz Burzykowski*+
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Companies:
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Hasselt University
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Address:
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, Diepenbeek, International, 3590, Belgium
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Keywords:
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surrogate endpoint ;
validation ;
meta-analytic approach
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Abstract:
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Following the proposal of Daniels and Hughes (1997), Buyse et al. (2000) formalized and developed a framework for the validation of surrogate endpoints by using data from multiple clinical trials. The framework has been termed the meta-analytic approach to the validation of surrogate endpoints. In the past decade, the approach has become a focus of an intensive research. As a result, many methods have been developed. Moreover, a better understanding of the advantages and limitations of the approach has been acquired. In this paper, an attempt to summarize the benefits and issues will be undertaken, together with a description of the most recent solutions proposed to tackle some of the problems.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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