This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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113
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 2, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract - #306859 |
Title:
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Surrogate Endpoint: New Statistical Definition and Evaluation
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Author(s):
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Yongming Qu*+
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Companies:
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Eli Lilly and Company
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Address:
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, Indianapolis, IN, 46033, USA
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Keywords:
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biomarker ;
surrogate marker ;
surrogate endpoint
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Abstract:
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Statistical definition and evaluation of the surrogate endpoint can be dated back to Prentice (Statistics in Medicine, 1989: 8: 431-440). Prentice proposed a necessary and sufficient condition for surrogate endpoint and a set of operational criteria. Subsequent work includes the concept of proportion of treatment effect and general association for both individual studies and meta-analysis approach. There seems a confusion among which statistical methods are appropriate to use. This research will review the existing methods and provide new definitions of biomarker, surrogate marker and surrogate endpoint. A new concept for the evaluation of surrogate endpoint will also be provided with some examples from clinical trials.
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