This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 43
Type: Contributed
Date/Time: Sunday, August 1, 2010 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #306750
Title: Robust Testing in Matched Case-Control Association Studies
Author(s): Yong Zang*+ and Wing Kam Fung and Gang Zheng
Companies: The University of Hong Kong and The University of Hong Kong and National Institutes of Health
Address: , , ,
Keywords: case-control ; association study ; matching design ; robust tests ; genetic model
Abstract:

The matched trend test (MTT) developed using a conditional logistic regression has been proposed to test for association in matched case-control studies to control the bias of known confounding effects. This test, however, may suffer from a substantial loss of power when the underlying genetic model is unknown and incorrectly specified. Thus, it is useful to derive tests obtaining the plausible power against all common genetic models. For this purpose, four robust tests-the MAX3 test, two-degrees-of-freedom test, stratified genetic model selection (SGMS) and exclusion (SGME) tests are discussed in this talk. The common feature of these tests is that they are all robust tests against genetic models while eliminating the effect of confounding factors by adopting a matching framework.


The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program




2010 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.