This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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426
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Type:
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Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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International Chinese Statistical Association
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Abstract - #306649 |
Title:
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Depression, Fracture Risk, and Bone Loss: A Meta-Analysis of Cohort Studies
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Author(s):
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Qing Wu*+ and Jianing Liu and Juan F. Gallegos-Orozco and Joseph G. Hentz
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Companies:
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Mayo Clinic and Arizona State University and Mayo Clinic and Mayo Clinic
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Address:
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13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA
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Keywords:
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Meta-analysis ;
Depression ;
Fracture ;
Bone
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Abstract:
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Whether depression can increase the risk of bone fractures is uncertain. Using a random-effects model, this meta-analysis pooled results from 14 qualifying individual cohort studies, which were identified by a standard protocol. In studies that reported HR as outcomes (6 studies [n=108,157]), depression was associated with a 17% increase in fracture risk (HR=1.17; 95% CI, 1.00-1.36; P=.05); in studies that reported RR (4 studies [n=33,428]), depression was associated with a 52% increase in risk (RR, 1.52; 95% CI, 1.26-1.85; P?.001). In studies that reported bone mineral density as an outcome (5 studies [n=8,931]), depression was associated with a reduced annualized bone loss rate of 0.25% (0.05%-0.45%; P=.02) at the hip and 0.29% (-0.07%-0.64%; P=.11) at the spine. These results indicate that depression was associated with a significantly increased risk of fractures and bone loss.
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