This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 515
Type: Contributed
Date/Time: Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #306628
Title: MicroRNA-Guided Gene Classifier in Colorectal Cancer
Author(s): Dung-Tsa Chen*+ and Timothy Yeatman and William Fulp and Mike Gruidl
Companies: Moffitt Cancer Center & Research Institute and Moffitt Cancer Center & Research Institute and Moffitt Cancer Center & Research Institute and Moffitt Cancer Center & Research Institute
Address: 12902 Magnolia Drive, Tampa, FL, 33612,
Keywords: Gene expression ; MicroRNA
Abstract:

Gene expression is quite noisy and key genes may have subtle change, not dramatic change in colorectal cancer. As a result, classifier using mRNA only may not predict well. Alternative strategy is needed to help identify regulated genes for clinical utility. In this study, we use miRNA to guide selection of regulated genes. This approach yields promising results in prediction compared to mRNA only classifiers.


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